The Croatia international remained on the bench for the Blues’ win against Everton at Goodison Park last weekend.
The midfielder is struggling with knee problems and will miss the meeting with Spurs at Stamford Bridge on Sunday.
“Kova is unfortunately injured and has problems with his knee,” Tuchel said on Friday.
‘We decided to take a step back and increase the treatment time and reduce the stress that comes from training to get a normal response before we start again.’
The rest of Tuchel’s squad are available for selection, apart from Marcos Alonso, who is on the verge of sealing a move to Barcelona.
Marcos Alonso is not in training at the moment as he tries to complete his transfer, so he will not be in action on Sunday.
‘Everyone else is available.’
The Blues go up against a Spurs side that comfortably beat Southampton 4-1 in their Premier League opener.
This summer, the north Londoners have strengthened a squad which already includes the prolific duo of Harry Kane and Son Heung-min.
When asked about the secret to keeping the aforementioned pair quiet, Tuchel said: ‘I’m not going to tell you.
‘The [Spurs] have a pattern in their offensive pressure and how they defend.
– It is important that we are good on the ball, the dominant team, and hopefully put the game in the opponents’ half.
‘Then we have to control the counter attack. They are perhaps one of the best teams in the world on the counter attack. We did a great job last season of shutting it down.’
MORE: Chelsea asked to pay world record fee to sign Wesley Fofana from Leicester City
MORE: ‘I’m here to win’ – Raheem Sterling aims for Champions League glory with Chelsea
For more stories like this, check out our sports page.
Follow Metro Sport for the latest news on
facebook, Twitter and Instagram.